Haoyu Cheng, PhD, assistant professor of biomedical informatics and data science at Yale School of Medicine, has developed a new algorithm capable of building
This leap was made possible by combining two advances. First, sequencing chemistry has improved, so common techniques are now accurate enough to support high-quality assembly. Second, we redesigned the assembly algorithm to better model the remaining errors in genetic data while also improving efficiency. Think of it like reading slightly blurred text—our algorithm can figure out what unclear letters should be by recognizing patterns and using context from surrounding sequences.